General Information

  • ID:  hor001782
  • Uniprot ID:  P83350
  • Protein name:  FMRFamide-1
  • Gene name:  NA
  • Organism:  Sarcophaga bullata (Grey flesh fly) (Neobellieria bullata)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Neobellieria (subgenus), Sarcophaga (genus), Sarcophaginae (subfamily), Sarcophagidae (family), Oestroidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QPSQDFMRF
  • Length:  9(1-9)
  • Propeptide:  QPSQDFMRF
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T9 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Has modulatory actions at skeletal neuromuscular junctions
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9VU58-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q9VU58-F1.pdbhor001782_AF2.pdbhor001782_ESM.pdb

Physical Information

Mass: 129816 Formula: C51H74N14O15S
Absent amino acids: ACEGHIKLNTVWY Common amino acids: FQ
pI: 6.34 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: -110 Boman Index: -2981
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 7773.33 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  12438685
  • Title:  Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor.
  • PubMed ID:  18789334
  • Title:  Extended FMRFamides in dipteran insects: conservative expression in the neuroendocrine system is accompanied by rapid sequence evolution.